Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw

OBJECTIVE: We hypothesized that patients with bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) accumulate higher levels of BP in bone than those without BRONJ. STUDY DESIGN: Using the Pmetrics(®) package and published data, we designed a population pharmacokinetic model of pamidronate co...

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Detalhes bibliográficos
Main Authors: Sedghizadeh, Parish P., Jones, Allan C., LaVallee, Chris, Jelliffe, Roger W., Le, Anh D., Lee, Peter, Kiss, Andrew, Neely, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545087/
https://ncbi.nlm.nih.gov/pubmed/23246224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oooo.2012.08.455
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