Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting

Insulin suppresses secretion of very low density lipoprotein (VLDL) apolipoprotein (apo) B in primary rodent hepatocytes (RH) by favoring the degradation of B100, the larger form of apo B, through post-endoplasmic reticulum proteolysis. Sortilin 1 (sort1), a multi-ligand sorting receptor, has been p...

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Bibliographic Details
Main Authors:	Chamberlain, Jeffrey M., O’Dell, Colleen, Sparks, Charles E., Sparks, Janet D.
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3544973/ https://ncbi.nlm.nih.gov/pubmed/23159624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.11.022
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Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting

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