The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence and Apoptosis in Association with Accumulation of DNA Damage Markers

Sesquiterpene lactones (SLs) are plant-derived compounds that display anti-cancer effects. Some SLs derivatives have a marked killing effect on cancer cells and have therefore reached clinical trials. Little is known regarding the mechanism of action of SLs. We studied the responses of human cancer...

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Main Authors: Costantino, Valeria V., Mansilla, Sabrina F., Speroni, Juliana, Amaya, Celina, Cuello-Carrión, Darío, Ciocca, Daniel R., Priestap, Horacio A., Barbieri, Manuel A., Gottifredi, Vanesa, Lopez, Luis A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544853/
https://ncbi.nlm.nih.gov/pubmed/23341930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053168
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