Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12...

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Autores principales: Afrikanova, Tatiana, Serruys, Ann-Sophie K., Buenafe, Olivia E. M., Clinckers, Ralph, Smolders, Ilse, de Witte, Peter A. M., Crawford, Alexander D., Esguerra, Camila V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544809/
https://ncbi.nlm.nih.gov/pubmed/23342097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054166
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