JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

BACKGROUND: Proopiomelanocortin (POMC)-derived beta-endorphin(1-31) from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment such analgesic effects. RESULTS: Interleukin-4...

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Autors principals: Busch-Dienstfertig, Melanie, Labuz, Dominika, Wolfram, Theresa, Vogel, Nicole N, Stein, Christoph
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544692/
https://ncbi.nlm.nih.gov/pubmed/23146666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-83
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