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Treatment of Halogen Bonding in the OPLS-AA Force Field; Application to Potent Anti-HIV Agents

The representation of chlorine, bromine, and iodine in aryl halides has been modified in the OPLS-AA and OPLS/CM1A force fields in order to incorporate halogen bonding. The enhanced force fields, OPLS-AAx and OPLS/CM1Ax, have been tested in calculations on gas-phase complexes of halobenzenes with Le...

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Autors principals: Jorgensen, William L., Schyman, Patric
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544186/
https://ncbi.nlm.nih.gov/pubmed/23329896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct300180w
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