MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

Evidence for a regulatory role of the miR-34 family in senescence is growing. However, the exact role of miR-34 in aging in vivo remains unclear. Here, we report that a mir-34 loss-of-function mutation in Caenorhabditis elegans markedly delays the age-related physiological decline, extends lifespan,...

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Detaylı Bibliyografya
Asıl Yazarlar: Yang, Jurong, Chen, Dapeng, He, Yani, Meléndez, Alicia, Feng, Zhe, Hong, Quan, Bai, Xueyuan, Li, Qinggang, Cai, Guangyan, Wang, Jianzhong, Chen, Xiangmei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Netherlands 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543738/
https://ncbi.nlm.nih.gov/pubmed/22081425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9324-3
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