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Feedback inhibition of ENaC during acute sodium loading in vivo

The epithelial Na(+) channel (ENaC) is tightly regulated by sodium intake to maintain whole body sodium homeostasis. In addition, ENaC is inhibited by high levels of intracellular Na(+) [Na(+)](i), presumably to prevent cell Na(+) overload and swelling. However, it is not clear if this regulation is...

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Autors principals: Patel, Ankit B., Frindt, Gustavo, Palmer, Lawrence G.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543624/
https://ncbi.nlm.nih.gov/pubmed/23171553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00596.2012
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