BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing

Here, we show that dBCAS2 (CG4980, human Breast Carcinoma Amplified Sequence 2 ortholog) is essential for the viability of Drosophila melanogaster. We find that ubiquitous or tissue-specific depletion of dBCAS2 leads to larval lethality, wing deformities, impaired splicing, and apoptosis. More impor...

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Hoofdauteurs: Chen, Po-Han, Lee, Chia-I, Weng, Yu-Tzu, Tarn, Woan-Yuh, Tsao, Yeou-Ping, Kuo, Ping-Chang, Hsu, Pang-Hung, Huang, Chu-Wei, Huang, Chiun-Sheng, Lee, Hsiu-Hsiang, Wu, June-Tai, Chen, Show-Li
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543084/
https://ncbi.nlm.nih.gov/pubmed/23249746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.034835.112
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