Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice

In this study, we investigated the effects of long-term (9-month) treatment with pioglitazone (PIO; 20 mg/kg/d) in two animal models of Alzheimer's disease (AD)-related neural dysfunction and pathology: the PS1-KI(M146V) (human presenilin-1 (M146V) knock-in mouse) and 3xTg-AD (triple transgenic...

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Autors principals: Masciopinto, F, Di Pietro, N, Corona, C, Bomba, M, Pipino, C, Curcio, M, Di Castelnuovo, A, Ciavardelli, D, Silvestri, E, Canzoniero, L MT, Sekler, I, Pandolfi, A, Sensi, S L
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542623/
https://ncbi.nlm.nih.gov/pubmed/23254291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.189
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