Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Although BCL-2-associated X protein (BAX) and BCL-2 antagonist killer (BAK) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly estab...

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Main Authors: Paul, I, Chacko, A D, Stasik, I, Busacca, S, Crawford, N, McCoy, F, McTavish, N, Wilson, B, Barr, M, O'Byrne, K J, Longley, D B, Fennell, D A
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542622/
https://ncbi.nlm.nih.gov/pubmed/23254292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.186
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