Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

Survival of tumor cells is favored by mitochondrial changes that make death induction more difficult in a variety of stress conditions, such as exposure to chemotherapeutics. These changes are not fully characterized in tumor mitochondria, and include unbalance of the redox equilibrium, inhibition o...

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Hlavní autoři: Chiara, F, Gambalunga, A, Sciacovelli, M, Nicolli, A, Ronconi, L, Fregona, D, Bernardi, P, Rasola, A, Trevisan, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542620/
https://ncbi.nlm.nih.gov/pubmed/23235461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.184
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