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Human Quiescin-sulfhydryl Oxidase, QSOX1: Probing Internal Redox Steps by Mutagenesis

The flavoprotein Quiescin-sulfhydryl oxidase (QSOX) rapidly inserts disulfide bonds into unfolded, reduced proteins with the concomitant reduction of oxygen to hydrogen peroxide. This study reports the first heterologous expression and enzymological characterization of a human QSOX1 isoform. Like QS...

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Detalhes bibliográficos
Main Authors: Heckler, Erin J., Alon, Assaf, Fass, Deborah, Thorpe, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542536/
https://ncbi.nlm.nih.gov/pubmed/18393449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702522q
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