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Screening of selective histone deacetylase inhibitors by proteochemometric modeling

BACKGROUND: Histone deacetylase (HDAC) is a novel target for the treatment of cancer and it can be classified into three classes, i.e., classes I, II, and IV. The inhibitors selectively targeting individual HDAC have been proved to be the better candidate antitumor drugs. To screen selective HDAC in...

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Main Authors: Wu, Dingfeng, Huang, Qi, Zhang, Yida, Zhang, Qingchen, Liu, Qi, Gao, Jun, Cao, Zhiwei, Zhu, Ruixin
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542186/
https://ncbi.nlm.nih.gov/pubmed/22913517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-212
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