Screening of selective histone deacetylase inhibitors by proteochemometric modeling

BACKGROUND: Histone deacetylase (HDAC) is a novel target for the treatment of cancer and it can be classified into three classes, i.e., classes I, II, and IV. The inhibitors selectively targeting individual HDAC have been proved to be the better candidate antitumor drugs. To screen selective HDAC in...

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Hauptverfasser: Wu, Dingfeng, Huang, Qi, Zhang, Yida, Zhang, Qingchen, Liu, Qi, Gao, Jun, Cao, Zhiwei, Zhu, Ruixin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542186/
https://ncbi.nlm.nih.gov/pubmed/22913517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-212
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