Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

Induced pluripotent stem (iPS) cells generated using Yamanaka factors have great potential for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells, and most mouse iPS cells are not fully pluripotent, as evaluated by the tetraploid complementation assay (TCA); this...

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Main Authors: Jiang, Jing, Lv, Wenjian, Ye, Xiaoying, Wang, Lingbo, Zhang, Man, Yang, Hui, Okuka, Maja, Zhou, Chikai, Zhang, Xuan, Liu, Lin, Li, Jinsong
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541664/
https://ncbi.nlm.nih.gov/pubmed/23147797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.157
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