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Glutamine metabolism links growth factor signaling to the regulation of autophagy
Activation of the PI3K-AKT1-FOXO module by growth factors increases survival and stress resistance. We identified the gene encoding glutamine synthetase (GLUL, glutamate-ammonia ligase) as a novel transcriptional target of this signaling cascade. Growth factor removal increases glutamine synthetase...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3541306/ https://ncbi.nlm.nih.gov/pubmed/22996802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22152 |
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