Impaired autophagy and delayed autophagic clearance of transforming growth factor β-induced protein (TGFBI) in granular corneal dystrophy type 2

Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant disease characterized by a progressive age-dependent extracellular accumulation of transforming growth factor β-induced protein (TGFBI). Corneal fibroblasts from GCD2 patients also have progressive degenerative features, but the mecha...

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Detalhes bibliográficos
Main Authors: Choi, Seung-Il, Kim, Bong-Yoon, Dadakhujaev, Shorafidinkhuja, Oh, Jun-Young, Kim, Tae-Im, Kim, Joo Young, Kim, Eung Kweon
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541288/
https://ncbi.nlm.nih.gov/pubmed/22995918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.22067
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