Type 2 Diabetes Restricts Multipotency of Mesenchymal Stem Cells and Impairs Their Capacity to Augment Postischemic Neovascularization in db/db Mice

BACKGROUND: This study tested the hypothesis that type 2 diabetes restricts multipotency of db/db mesenchymal stem cells (MSCs), promotes their terminal differentiation into adipocytes rather than endothelial cells, thereby promotes adipocytic infiltration into ischemic muscles, and reduces their ca...

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Détails bibliographiques
Auteurs principaux: Yan, Jinglian, Tie, Guodong, Wang, Shouying, Messina, Katharine E., DiDato, Sebastian, Guo, Sujuan, Messina, Louis M.
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2012
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540677/
https://ncbi.nlm.nih.gov/pubmed/23316315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.002238
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