Defects of mtDNA Replication Impaired Mitochondrial Biogenesis During Trypanosoma cruzi Infection in Human Cardiomyocytes and Chagasic Patients: The Role of Nrf1/2 and Antioxidant Response

BACKGROUND: Mitochondrial dysfunction is a key determinant in chagasic cardiomyopathy development in mice; however, its relevance in human Chagas disease is not known. We determined if defects in mitochondrial biogenesis and dysregulation of peroxisome proliferator-activated receptor gamma (PPARγ) c...

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Bibliografske podrobnosti
Main Authors: Wan, Xianxiu, Gupta, Shivali, Zago, Maria P., Davidson, Mercy M., Dousset, Pierre, Amoroso, Alejandro, Garg, Nisha Jain
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540675/
https://ncbi.nlm.nih.gov/pubmed/23316324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.003855
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