Does Changing the Predicted Dynamics of a Phospholipase C Alter Activity and Membrane Binding?

The enzymatic activity of secreted phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes is associated with bacterial virulence. Although the PI-PLC active site has no obvious lid, molecular-dynamics simulations suggest that correlated loop motions may limit access to the active site, and t...

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Detalhes bibliográficos
Main Authors: Cheng, Jiongjia, Karri, Sashank, Grauffel, Cédric, Wang, Fang, Reuter, Nathalie, Roberts, Mary F., Wintrode, Patrick L., Gershenson, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540254/
https://ncbi.nlm.nih.gov/pubmed/23332071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.015
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