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Kinetics of Ligand-Receptor Interaction Reveals an Induced-Fit Mode of Binding in a Cyclic Nucleotide-Activated Protein

Many receptors and ion channels are activated by ligands. One key question concerns the binding mechanism. Does the ligand induce conformational changes in the protein via the induced-fit mechanism? Or does the protein preexist as an ensemble of conformers and the ligand selects the most complementa...

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Bibliografische gegevens
Hoofdauteurs: Peuker, Sebastian, Cukkemane, Abhishek, Held, Martin, Noé, Frank, Kaupp, U. Benjamin, Seifert, Reinhard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3540248/
https://ncbi.nlm.nih.gov/pubmed/23332059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3816
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