Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

The relationship between acidosis within the tumor microenvironment and radioresistance of hypoxic tumor cells remains unclear. Previously we reported that hypoxia-induced carbonic anhydrases (CA) IX and CAXII constitute a robust intracellular pH (pH(i))-regulating system that confers a survival adv...

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Detaylı Bibliyografya
Asıl Yazarlar: Doyen, Jérome, Parks, Scott K., Marcié, Serge, Pouysségur, Jacques, Chiche, Johanna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2013
Konular:
Oncology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539669/
https://ncbi.nlm.nih.gov/pubmed/23316475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00199
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