Dose-dependent protection on cisplatin-induced ototoxicity – an electrophysiological study on the effect of three antioxidants in the Sprague-Dawley rat animal model

BACKGROUND: Sprague-Dawley rats were used as an acute cisplatin ototoxicity model to compare the chemo-protective efficacy of 2 sulphur-containing antioxidants (D-methionine, N-L-acetylcysteine) and 1 seleno-organic compound (ebselen). Each putative chemo-protective agent was tested at 3 different d...

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Hauptverfasser: Lorito, Guiscardo, Hatzopoulos, Stavros, Laurell, Göran, Campbell, Kathleen C.M., Petruccelli, Joseph, Giordano, Pietro, Kochanek, Krzysztof, Sliwa, Lech, Martini, Alessandro, Skarzynski, Henryk
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Scientific Literature, Inc. 2011
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539615/
https://ncbi.nlm.nih.gov/pubmed/21804453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.881894
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