Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory

The NR2A:NR2B subunit ratio of the NMDA receptors is widely known to increase in the brain from postnatal development to sexual maturity and to aging, yet its impact on memory function remains speculative. We have generated forebrain-specific NR2A overexpression transgenic mice and show that these m...

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Huvudupphovsmän: Cui, Zhenzhong, Feng, Ruiben, Jacobs, Stephanie, Duan, Yanhong, Wang, Huimin, Cao, Xiaohua, Tsien, Joe Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539144/
https://ncbi.nlm.nih.gov/pubmed/23301157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01036
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