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Comparing Conformational Ensembles Using the Kullback-Leibler Divergence Expansion

We present a thermodynamical approach to identify changes in macromolecular structure and dynamics in response to perturbations such as mutations or ligand binding, using an expansion of the Kullback-Leibler Divergence that connects local population shifts in torsion angles to changes in the free en...

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Autors principals: McClendon, Christopher L., Hua, Lan, Barreiro, abriela, Jacobson, Matthew P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538811/
https://ncbi.nlm.nih.gov/pubmed/23316121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct300008d
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