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Tgfβ signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc
Ectopic expression of the transcription factors Oct4, Sox2, cMyc, and Klf4, as well as variants of this factor combination, are sufficient to confer a pluripotent state upon several differentiated cell types, generating induced pluripotent stem cells (iPSCs) [1-8]. The derivation of iPSCs is a highl...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538372/ https://ncbi.nlm.nih.gov/pubmed/19765992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.08.025 |
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