Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell to cell. To our knowledge, this is the first report of delivery of a therapeutic mRNA/protein via MVs for treatment of cancer. We first genera...

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Detalhes bibliográficos
Main Authors: Mizrak, Arda, Bolukbasi, Mehmet Fatih, Ozdener, Gokhan Baris, Brenner, Gary J, Madlener, Sibylle, Erkan, Erdogan Pekcan, Ströbel, Thomas, Breakefield, Xandra O, Saydam, Okay
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538300/
https://ncbi.nlm.nih.gov/pubmed/22910294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.161
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