N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

The ASPP2 (also known as 53BP2L) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing p53-dependent apoptosis via its C-terminal p53-binding domain. Mounting evidence also suggests that ASPP2 harbors important nonapoptotic p53-independent...

詳細記述

保存先:
書誌詳細
主要な著者: Wang, Zhiping, Liu, Yuangang, Takahashi, Maho, Van Hook, Kathryn, Kampa-Schittenhelm, Kerstin M., Sheppard, Brett C., Sears, Rosalie C., Stork, Philip J. S., Lopez, Charles D.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2013
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538245/
https://ncbi.nlm.nih.gov/pubmed/23248303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201514110
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料