N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

The ASPP2 (also known as 53BP2L) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing p53-dependent apoptosis via its C-terminal p53-binding domain. Mounting evidence also suggests that ASPP2 harbors important nonapoptotic p53-independent...

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Main Authors: Wang, Zhiping, Liu, Yuangang, Takahashi, Maho, Van Hook, Kathryn, Kampa-Schittenhelm, Kerstin M., Sheppard, Brett C., Sears, Rosalie C., Stork, Philip J. S., Lopez, Charles D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538245/
https://ncbi.nlm.nih.gov/pubmed/23248303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201514110
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