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Dynamic modulation of ANO1/TMEM16A HCO(3)(−) permeability by Ca(2+)/calmodulin
Anoctamin 1 (ANO1)/transmembrane protein 16A (TMEM16A) is a calcium-activated anion channel that may play a role in HCO(3)(−) secretion in epithelial cells. Here, we report that the anion selectivity of ANO1 is dynamically regulated by the Ca(2+)/calmodulin complex. Whole-cell current measurements i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538232/ https://ncbi.nlm.nih.gov/pubmed/23248295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211594110 |
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