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Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models
The identification of causative mutations in the (pro)granulin gene (GRN) has been a major breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated GRN mutations are leading to neurodegeneration through a “loss-of-function” mechanism, encouraging researchers to devel...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Humana Press Inc
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538123/ https://ncbi.nlm.nih.gov/pubmed/23239020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-012-8380-8 |
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