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Metabolic Preconditioning of Mammalian Cells: Mimetic Agents for Hypoxia Lack Fidelity in Promoting Phosphorylation of Pyruvate Dehydrogenase
Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3537919/ https://ncbi.nlm.nih.gov/pubmed/23138570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-012-1517-2 |
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