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Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyper-Reactivity and Thrombosis

RATIONALE: A prothrombotic state and increased platelet reactivity are common in pathophysiological conditions associated with oxidative stress and infections. Such conditions are associated with an appearance of altered-self ligands in circulation that can be recognized by Toll-like receptors (TLR)...

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Autori principali: Panigrahi, Soumya, Ma, Yi, Hong, Li, Gao, Detao, West, Xiaoxia Z., Salomon, Robert G., Byzova, Tatiana V., Podrez, Eugene A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537845/
https://ncbi.nlm.nih.gov/pubmed/23071157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.274241
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