High Expression of the Pi-Transporter SLC20A1/Pit1 in Calcific Aortic Valve Disease Promotes Mineralization through Regulation of Akt-1

The regulation of phosphate (Pi) handling is crucial during calcification of the aortic valve. Gene profiling of Pi transporters revealed that VIC culture expresses SLC201A1/Pit1 and SLC20A2/Pit2. On exposure to a mineralizing medium (2 mM Pi), the expression of Pi transporters in VIC culture is inc...

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Detalhes bibliográficos
Main Authors: El Husseini, Diala, Boulanger, Marie-Chloé, Fournier, Dominique, Mahmut, Ablajan, Bossé, Yohan, Pibarot, Philippe, Mathieu, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537628/
https://ncbi.nlm.nih.gov/pubmed/23308213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053393
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