Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes

To ascertain the genetic basis of pediatric Burkitt lymphoma (pBL), we performed clinical-grade next-generation sequencing of 182 cancer-related genes on 29 formalin-fixed, paraffin embedded primary pBL samples. Ninety percent of cases had at least one mutation or genetic alteration, most commonly i...

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Detalhes bibliográficos
Principais autores: Giulino-Roth, Lisa, Wang, Kai, MacDonald, Theresa Y., Mathew, Susan, Tam, Yifang, Cronin, Maureen T., Palmer, Gary, Lucena-Silva, Norma, Pedrosa, Francisco, Pedrosa, Marcia, Teruya-Feldstein, Julie, Bhagat, Govind, Alobeid, Bachir, Leoncini, Lorenzo, Bellan, Cristiana, Rogena, Emily, Pinkney, Kerice A., Rubin, Mark A., Ribeiro, Raul C., Yelensky, Roman, Tam, Wayne, Stephens, Philip J., Cesarman, Ethel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537311/
https://ncbi.nlm.nih.gov/pubmed/23091298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-437624
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