Loss of the Ciliary Kinase Nek8 Causes Left-Right Asymmetry Defects

A missense mutation in mouse Nek8, which encodes a ciliary kinase, produces the juvenile cystic kidneys (jck) model of polycystic kidney disease, but the functions of Nek8 are incompletely understood. Here, we generated a Nek8-null allele and found that homozygous mutant mice die at birth and exhibi...

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Detalhes bibliográficos
Main Authors: Manning, Danielle K., Sergeev, Mikhail, van Heesbeen, Roy G., Wong, Michael D., Oh, Jin-Hee, Liu, Yan, Henkelman, R. Mark, Drummond, Iain, Shah, Jagesh V., Beier, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537214/
https://ncbi.nlm.nih.gov/pubmed/23274954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050490
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