Prevalence of Germline TP53 Mutations in a Prospective Series of Unselected Patients with Adrenocortical Carcinoma

PURPOSE: Adrenocortical carcinoma (ACC) is a hallmark cancer in families with Li Fraumeni syndrome (LFS) caused by mutations in the TP53 gene. The prevalence of germline TP53 mutations in children diagnosed with ACC ranges from 50–97%. Although existing criteria advocate for TP53 testing in all pati...

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Main Authors: Raymond, Victoria M., Else, Tobias, Everett, Jessica N., Long, Jessica M., Gruber, Stephen B., Hammer, Gary D.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2013
Fag:
JCEM Online: Advances in Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537086/
https://ncbi.nlm.nih.gov/pubmed/23175693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2198
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