Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

RATIONALE: Accelerated lung function decline is a key COPD phenotype; however its genetic control remains largely unknown. METHODS: We performed a genome-wide association study using the Illumina Human660W-Quad v.1_A BeadChip. Generalized estimation equations were used to assess genetic contribution...

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Hauptverfasser: Hansel, Nadia N, Ruczinski, Ingo, Rafaels, Nicholas, Sin, Don D, Daley, Denise, Malinina, Alla, Huang, Lili, Sandford, Andrew, Murray, Tanda, Kim, Yoonhee, Vergara, Candelaria, Heckbert, Susan R, Psaty, Bruce M, Li, Guo, Elliott, W. Mark, Aminuddin, Farzian, Dupuis, Josée, O’Connor, George, Doheny, Kimberly, Scott, Alan F, Boezen, H Marike, Postma, Dirkje S, Smolonska, Joanna, Zanen, Pieter, Mohamed Hoesein, Firdaus A, de Koning, Harry J, Crystal, Ron, Tanaka, Toshiko, Ferrucci, Luigi, Silverman, Edwin, Wan, Emily, Vestbo, Jorgen, Lomas, David A, Connett, John, Wise, Robert A, Neptune, Enid R, Mathias, Rasika A, Paré, Peter D, Beaty, Terri H, Barnes, Kathleen C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536920/
https://ncbi.nlm.nih.gov/pubmed/22986903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-012-1219-6
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