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Development of novel cell lines of diabetic dysfunction model fit for cell-based screening tests of medicinal materials
Pdx-1 and Irs-1, genes highly associated with diabetes onset, were knocked down in mouse embryonic stem (ES) cells in order to develop cell line models for diabetes. ES cells with different gene knockdown levels were induced to differentiate to the stage of insulin production. Among the cell lines t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536874/ https://ncbi.nlm.nih.gov/pubmed/22777586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-012-9466-x |
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