Identification of the Enzyme Responsible for N-Acetylation of Norfloxacin by Microbacterium sp. Strain 4N2-2

Microbacterium sp. 4N2-2, isolated from a wastewater treatment plant, converts the antibacterial fluoroquinolone norfloxacin to N-acetylnorfloxacin and three other metabolites. Because N-acetylation results in loss of antibacterial activity, identification of the enzyme responsible is important for...

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Autores principales: Kim, Dae-Wi, Feng, Jinhui, Chen, Huizhong, Kweon, Ohgew, Gao, Yuan, Yu, Li-Rong, Burrowes, Vanessa J., Sutherland, John B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Environmental Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536110/
https://ncbi.nlm.nih.gov/pubmed/23104417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02347-12
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