Inhibition of Streptococcus pneumoniae Penicillin-Binding Protein 2x and Actinomadura R39 DD-Peptidase Activities by Ceftaroline

Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae penicillin-binding protein 2x (PBP2x) by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12,600 M(−1) s(−1)) to explain the sensitivity of...

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Bibliographic Details
Main Authors: Zervosen, Astrid, Zapun, André, Frère, Jean-Marie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535952/
https://ncbi.nlm.nih.gov/pubmed/23147739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01593-12
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