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Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents
Herein we developed a new “smart” Gd-based MR contrast agent (i.e., 1) which is susceptive to furin, a protease overexpressed in tumor. Under the action of furin, 1 condenses to form dimers (1-Ds) and the latter self-assemble into gadolinium nanparticles (Gd-NPs). Relaxivity of 1-D is more than 2 fo...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535584/ https://ncbi.nlm.nih.gov/pubmed/23289066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01024 |
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