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Beyond counts and shapes: Studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy

Because dendritic spines are the sites of excitatory synapses, pathological changes in spine morphology should be considered as part of pathological changes in neuronal circuitry in the forms of synaptic connections and connectivity strength. In the past, spine pathology has usually been measured by...

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Main Authors: Kuwajima, Masaaki, Spacek, Josef, Harris, Kristen M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535574/
https://ncbi.nlm.nih.gov/pubmed/22561733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.04.061
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