The Effect of CR1 on Brain Amyloid Burden during Aging and its Modification by APOE Genotype

BACKGROUND: The rs3818361 single nucleotide polymorphism in CR1 is associated with increased risk of Alzheimer's disease (AD). Although this novel variant is associated with a small effect size and, is unlikely to be useful as a predictor of AD risk, it may provide insights into AD pathogenesis...

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Autori principali: Thambisetty, Madhav, An, Yang, Nalls, Michael, Sojkova, Jitka, Swaminathan, Shanker, Zhou, Yun, Singleton, Andrew B., Wong, Dean F., Ferrucci, Luigi, Saykin, Andrew J., Resnick, Susan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535537/
https://ncbi.nlm.nih.gov/pubmed/23022416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.08.015
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