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A System of Repressor Gradients Spatially Organizes the Boundaries of “Morphogen-dependent” Target Genes
The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen that positions boundaries of target genes via threshold-dependent activation mechanisms. Here we analyze 66 Bcd-dependent regulatory elements, and show that their boundaries are positioned primarily by repressiv...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535481/ https://ncbi.nlm.nih.gov/pubmed/22541432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.018 |
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