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Modeling the evolution of drug resistance in malaria
Plasmodium falciparum, the causal agent of malaria, continues to evolve resistance to frontline therapeutics such as chloroquine and sulfadoxine-pyrimethamine. Here we study the amino acid replacements in dihydrofolate reductase (DHFR) that confer resistance to pyrimethamine while still binding the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535480/ https://ncbi.nlm.nih.gov/pubmed/23179493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-012-9618-2 |
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