Frontline Treatment of Localized Osteosarcoma Without Methotrexate: Results of the St. Jude Children's Research Hospital OS99 Trial

BACKGROUND: Standard treatment of osteosarcoma includes cisplatin and high-dose methotrexate (HDMTX); both agents exert significant toxicity, and HDMTX requires complex pharmacokinetic monitoring and leucovorin rescue. In our previous OS91 trial, treatment of localized disease with carboplatin, ifos...

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Main Authors: Daw, Najat C., Neel, Michael D., Rao, Bhaskar N., Billups, Catherine A., Wu, Jianrong, Jenkins, Jesse J., Quintana, Juan, Luchtman-Jones, Lori, Villarroel, Milena, Santana, Victor M.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535449/
https://ncbi.nlm.nih.gov/pubmed/21656756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.25715
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