Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors

PURPOSE: Omacetaxine mepesuccinate is a first-in-class cephalotaxine demonstrating clinical activity in chronic myeloid leukemia. A subcutaneous (SC) formulation demonstrated efficacy and safety in phase 1/2 trials in patients previously treated with ≥1 tyrosine kinase inhibitor. This study assessed...

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Главные авторы: Nemunaitis, John, Mita, Alain, Stephenson, Joe, Mita, Monica M., Sarantopoulos, John, Padmanabhan-Iyer, Swami, Nanda, Nisha, Gleich, Lyon, Benichou, Annie-Claude, Craig, Adam
Формат: Artigo
Язык:Inglês
Опубликовано: Springer-Verlag 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535355/
https://ncbi.nlm.nih.gov/pubmed/23053254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1963-2
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