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Synthesis of 1,2,4-Triazines and the Triazinoisoquinolinedione DEF Ring System of Noelaquinone()

The intramolecular Staudinger aza-Wittig reaction is used for a general synthesis of 1,2,5,6-tetrahydro-1,2,4-triazines, a structural motif reported for the natural product noelaquinone. The DEF moiety of noelaquinone was obtained in 13 steps and 2% overall yield, and the structure of the synthetic...

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Autors principals: Cao, Liming, Maciejewski, John P., Elzner, Stephan, Amantini, David, Wipf, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535313/
https://ncbi.nlm.nih.gov/pubmed/22473572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob25353d
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