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Hydrophobicity of Methylated DNA as a Possible Mechanism for Gene Silencing

AFM images show that chromatin reconstituted on methylated DNA (meDNA) is compacted when imaged under water. Chromatin reconstituted on unmethylated DNA is less compacted and less sensitive to hydration. These differences must reflect changes in the physical properties of DNA on methylation, but pri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kaur, Parminder, Plochberger, Birgit, Costa, Peter, Cope, Stephanie M., Vaiana, Sara M., Lindsay, Stuart
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534983/
https://ncbi.nlm.nih.gov/pubmed/23196865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/1478-3975/9/6/065001
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