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Hydrophobicity of Methylated DNA as a Possible Mechanism for Gene Silencing
AFM images show that chromatin reconstituted on methylated DNA (meDNA) is compacted when imaged under water. Chromatin reconstituted on unmethylated DNA is less compacted and less sensitive to hydration. These differences must reflect changes in the physical properties of DNA on methylation, but pri...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534983/ https://ncbi.nlm.nih.gov/pubmed/23196865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/1478-3975/9/6/065001 |
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