Retrotransposon Insertion in the T-cell Acute Lymphocytic Leukemia 1 (Tal1) Gene Is Associated with Severe Renal Disease and Patchy Alopecia in Hairpatches (Hpt) Mice

“Hairpatches” (Hpt) is a naturally occurring, autosomal semi-dominant mouse mutation. Hpt/Hpt homozygotes die in utero, while Hpt/+ heterozygotes exhibit progressive renal failure accompanied by patchy alopecia. This mutation is a model for the rare human disorder “glomerulonephritis with sparse hai...

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Bibliographic Details
Main Authors: Hosur, Vishnu, Cox, Melissa L., Burzenski, Lisa M., Riding, Rebecca L., Alley, Lynn, Lyons, Bonnie L., Kavirayani, Anoop, Martin, Kimberly A., Cox, Gregory A., Johnson, Kenneth R., Shultz, Leonard D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534690/
https://ncbi.nlm.nih.gov/pubmed/23301070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053426
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